An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis
المؤلفون المشاركون
Zhao, Cheng-Wu
Gao, Yu-Hang
Song, Wen-Xia
Liu, Bo
Ding, Lu
Dong, Ning
Qi, Xin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Resistin may be involved in the pathogenesis of osteoarthritis (OA), but a systematic understanding of the role of resistin in OA is lacking.
Methods.
We reviewed studies that evaluated the role of resistin in OA.
The expression levels of resistin in vitro experiments and OA/rheumatoid arthritis (RA) patients were analyzed.
We also studied potential resistin receptors and the signaling pathways that these receptors activate, ultimately leading to cartilage degeneration.
Results.
Resistin levels in both the serum and synovial fluid were higher in OA and RA patients than in healthy subjects.
Overall, resistin levels are much higher in serum than in synovial fluid.
In human cartilage, resistin induces the expression of proinflammatory factors such as degradative enzymes, leading to the inhibition of cartilage matrix synthesis, perhaps by binding to Toll-like receptor 4 and the adenylyl cyclase-associated protein 1 receptor, which then activates the p38-mitogen-activated phosphate kinase, protein kinase A–cyclic AMP, nuclear factor-κB, and C/enhancer-binding protein β signaling pathways.
Conclusion.
Resistin levels are higher in OA patients than in healthy controls; however, the precise role of resistin in the pathogenesis of OA needs to be studied further.
Resistin may be a novel therapeutic target in OA in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Cheng-Wu& Gao, Yu-Hang& Song, Wen-Xia& Liu, Bo& Ding, Lu& Dong, Ning…[et al.]. 2019. An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192605
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Cheng-Wu…[et al.]. An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1192605
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Cheng-Wu& Gao, Yu-Hang& Song, Wen-Xia& Liu, Bo& Ding, Lu& Dong, Ning…[et al.]. An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192605
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192605
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر