An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis
Joint Authors
Zhao, Cheng-Wu
Gao, Yu-Hang
Song, Wen-Xia
Liu, Bo
Ding, Lu
Dong, Ning
Qi, Xin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Resistin may be involved in the pathogenesis of osteoarthritis (OA), but a systematic understanding of the role of resistin in OA is lacking.
Methods.
We reviewed studies that evaluated the role of resistin in OA.
The expression levels of resistin in vitro experiments and OA/rheumatoid arthritis (RA) patients were analyzed.
We also studied potential resistin receptors and the signaling pathways that these receptors activate, ultimately leading to cartilage degeneration.
Results.
Resistin levels in both the serum and synovial fluid were higher in OA and RA patients than in healthy subjects.
Overall, resistin levels are much higher in serum than in synovial fluid.
In human cartilage, resistin induces the expression of proinflammatory factors such as degradative enzymes, leading to the inhibition of cartilage matrix synthesis, perhaps by binding to Toll-like receptor 4 and the adenylyl cyclase-associated protein 1 receptor, which then activates the p38-mitogen-activated phosphate kinase, protein kinase A–cyclic AMP, nuclear factor-κB, and C/enhancer-binding protein β signaling pathways.
Conclusion.
Resistin levels are higher in OA patients than in healthy controls; however, the precise role of resistin in the pathogenesis of OA needs to be studied further.
Resistin may be a novel therapeutic target in OA in the future.
American Psychological Association (APA)
Zhao, Cheng-Wu& Gao, Yu-Hang& Song, Wen-Xia& Liu, Bo& Ding, Lu& Dong, Ning…[et al.]. 2019. An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192605
Modern Language Association (MLA)
Zhao, Cheng-Wu…[et al.]. An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1192605
American Medical Association (AMA)
Zhao, Cheng-Wu& Gao, Yu-Hang& Song, Wen-Xia& Liu, Bo& Ding, Lu& Dong, Ning…[et al.]. An Update on the Emerging Role of Resistin on the Pathogenesis of Osteoarthritis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192605