![](/images/graphics-bg.png)
Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types
المؤلفون المشاركون
Rivoltini, L.
Stacchiotti, Silvia
Tazzari, Marcella
Brich, Silvia
Tuccitto, Alessandra
Bozzi, Fabio
Beretta, Valeria
Spagnuolo, Rosalin D.
Negri, Tiziana
Deraco, Marcello
Baratti, Dario
Camisaschi, Chiara
Villa, Antonello
Vergani, Barbara
Pilotti, Silvana
Castelli, Chiara
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-29
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Malignant peritoneal mesothelioma (MpM), arising in the setting of local inflammation, is a rare aggressive tumour with a poor prognosis and limited therapeutic options.
The three major MpM histological variants, epithelioid (E-MpMs), biphasic, and sarcomatoid MpMs (S-MpMs), are characterised by an increased aggressiveness and enhanced levels of EZH2 expression.
To investigate the MpM immune contexture along the spectrum of MpM histotypes, an extended in situ analysis was performed on a series of 14 cases.
Tumour-infiltrating immune cells and their functionality were assessed by immunohistochemistry, immunofluorescence, qRT-PCR, and flow cytometry analysis.
MpMs are featured by a complex immune landscape modulated along the spectrum of MpM variants.
Tumour-infiltrating T cells and evidence for pre-existing antitumour immunity are mainly confined to E-MpMs.
However, Th1-related immunological features are progressively impaired in the more aggressive forms of E-MpMs and completely lost in S-MpM.
Concomitantly, E-MpMs show also signs of active immune suppression, such as the occurrence of Tregs and Bregs and the expression of the immune checkpoint inhibitory molecules PD1 and PDL1.
This study enriches the rising rationale for immunotherapy in MpM and points to the E-MpMs as the most immune-sensitive MpM histotypes, but it also suggests that synergistic interventions aimed at modifying the tumour microenvironment (TME) should be considered to make immunotherapy beneficial for these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tazzari, Marcella& Brich, Silvia& Tuccitto, Alessandra& Bozzi, Fabio& Beretta, Valeria& Spagnuolo, Rosalin D.…[et al.]. 2018. Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1192659
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tazzari, Marcella…[et al.]. Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types. Journal of Immunology Research No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1192659
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tazzari, Marcella& Brich, Silvia& Tuccitto, Alessandra& Bozzi, Fabio& Beretta, Valeria& Spagnuolo, Rosalin D.…[et al.]. Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1192659
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192659
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)