Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types
Joint Authors
Rivoltini, L.
Stacchiotti, Silvia
Tazzari, Marcella
Brich, Silvia
Tuccitto, Alessandra
Bozzi, Fabio
Beretta, Valeria
Spagnuolo, Rosalin D.
Negri, Tiziana
Deraco, Marcello
Baratti, Dario
Camisaschi, Chiara
Villa, Antonello
Vergani, Barbara
Pilotti, Silvana
Castelli, Chiara
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Malignant peritoneal mesothelioma (MpM), arising in the setting of local inflammation, is a rare aggressive tumour with a poor prognosis and limited therapeutic options.
The three major MpM histological variants, epithelioid (E-MpMs), biphasic, and sarcomatoid MpMs (S-MpMs), are characterised by an increased aggressiveness and enhanced levels of EZH2 expression.
To investigate the MpM immune contexture along the spectrum of MpM histotypes, an extended in situ analysis was performed on a series of 14 cases.
Tumour-infiltrating immune cells and their functionality were assessed by immunohistochemistry, immunofluorescence, qRT-PCR, and flow cytometry analysis.
MpMs are featured by a complex immune landscape modulated along the spectrum of MpM variants.
Tumour-infiltrating T cells and evidence for pre-existing antitumour immunity are mainly confined to E-MpMs.
However, Th1-related immunological features are progressively impaired in the more aggressive forms of E-MpMs and completely lost in S-MpM.
Concomitantly, E-MpMs show also signs of active immune suppression, such as the occurrence of Tregs and Bregs and the expression of the immune checkpoint inhibitory molecules PD1 and PDL1.
This study enriches the rising rationale for immunotherapy in MpM and points to the E-MpMs as the most immune-sensitive MpM histotypes, but it also suggests that synergistic interventions aimed at modifying the tumour microenvironment (TME) should be considered to make immunotherapy beneficial for these patients.
American Psychological Association (APA)
Tazzari, Marcella& Brich, Silvia& Tuccitto, Alessandra& Bozzi, Fabio& Beretta, Valeria& Spagnuolo, Rosalin D.…[et al.]. 2018. Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1192659
Modern Language Association (MLA)
Tazzari, Marcella…[et al.]. Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types. Journal of Immunology Research No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1192659
American Medical Association (AMA)
Tazzari, Marcella& Brich, Silvia& Tuccitto, Alessandra& Bozzi, Fabio& Beretta, Valeria& Spagnuolo, Rosalin D.…[et al.]. Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1192659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192659