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Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor
المؤلفون المشاركون
Venugopala, K. N.
Nair, Anroop B.
Patel, Snehal S.
Savjani, Jignasa K.
Shah, Jigar N.
Morsy, Mohamed A.
El-Sheikh, Azza A. K.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Despite the usefulness of glucocorticoids, they may cause hazardous side effects that limit their use.
Searching for compounds that are as equally efficient as glucocorticoids, but with less side effects, the current study compared plant steroids, namely, glycyrrhetinic acid, guggulsterone, boswellic acid, withaferin A, and diosgenin with the classical glucocorticoid, fluticasone.
This was approached both in silico using molecular docking against glucocorticoid receptor (GR) and in vivo in two different animal models.
All tested compounds interacted with GR, but only boswellic acid and withaferin A showed docking results comparable to fluticasone, as well as similar in vivo anti-inflammatory effects, by significantly decreasing serum levels of interleukin-6 and tumor necrosis factor-α in cotton pellet-induced granuloma in rats.
In addition, both compounds significantly decreased the percent of change in ear weight in croton oil-induced ear edema in mice and the granuloma weight in cotton pellet-induced granuloma in rats, to levels comparable to that of fluticasone.
Both boswellic acid and withaferin A had no effect on adrenal index, but only withaferin A significantly increased the thymus index.
In conclusion, boswellic acid may have comparable anti-inflammatory effects to fluticasone with fewer side effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morsy, Mohamed A.& Patel, Snehal S.& El-Sheikh, Azza A. K.& Savjani, Jignasa K.& Nair, Anroop B.& Shah, Jigar N.…[et al.]. 2019. Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192760
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morsy, Mohamed A.…[et al.]. Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor. Mediators of Inflammation No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1192760
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morsy, Mohamed A.& Patel, Snehal S.& El-Sheikh, Azza A. K.& Savjani, Jignasa K.& Nair, Anroop B.& Shah, Jigar N.…[et al.]. Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192760
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192760
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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