![](/images/graphics-bg.png)
Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor
Joint Authors
Venugopala, K. N.
Nair, Anroop B.
Patel, Snehal S.
Savjani, Jignasa K.
Shah, Jigar N.
Morsy, Mohamed A.
El-Sheikh, Azza A. K.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite the usefulness of glucocorticoids, they may cause hazardous side effects that limit their use.
Searching for compounds that are as equally efficient as glucocorticoids, but with less side effects, the current study compared plant steroids, namely, glycyrrhetinic acid, guggulsterone, boswellic acid, withaferin A, and diosgenin with the classical glucocorticoid, fluticasone.
This was approached both in silico using molecular docking against glucocorticoid receptor (GR) and in vivo in two different animal models.
All tested compounds interacted with GR, but only boswellic acid and withaferin A showed docking results comparable to fluticasone, as well as similar in vivo anti-inflammatory effects, by significantly decreasing serum levels of interleukin-6 and tumor necrosis factor-α in cotton pellet-induced granuloma in rats.
In addition, both compounds significantly decreased the percent of change in ear weight in croton oil-induced ear edema in mice and the granuloma weight in cotton pellet-induced granuloma in rats, to levels comparable to that of fluticasone.
Both boswellic acid and withaferin A had no effect on adrenal index, but only withaferin A significantly increased the thymus index.
In conclusion, boswellic acid may have comparable anti-inflammatory effects to fluticasone with fewer side effects.
American Psychological Association (APA)
Morsy, Mohamed A.& Patel, Snehal S.& El-Sheikh, Azza A. K.& Savjani, Jignasa K.& Nair, Anroop B.& Shah, Jigar N.…[et al.]. 2019. Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192760
Modern Language Association (MLA)
Morsy, Mohamed A.…[et al.]. Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor. Mediators of Inflammation No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1192760
American Medical Association (AMA)
Morsy, Mohamed A.& Patel, Snehal S.& El-Sheikh, Azza A. K.& Savjani, Jignasa K.& Nair, Anroop B.& Shah, Jigar N.…[et al.]. Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192760
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192760