HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1
المؤلفون المشاركون
Chacon-Salinas, Rommel
Monroy-García, A.
Vallejo-Castillo, Luis
Weiss-Steider, Benny
de Lourdes Mora-García, María
López-Cisneros, Sofía
Gutiérrez-Serrano, Vianey
García-Rocha, Rosario
Hernández-Montes, Jorge
Sánchez-Peña, Héctor I.
Ávila-Ibarra, Luis Roberto
Don-López, Christian Azucena
Muñóz-Godínez, Ricardo
Pineda, Daniela Berenice Torres
Pérez-Tapia, Sonia Mayra
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The development of cervical cancer (CeCa) is associated with high-risk human papilloma virus (HR-HPV) infections, mainly HPV-16, which is present in more than 50% of cases.
The presence of immunosuppressive factors in the early stages of the disease is also strongly linked to CeCa progression.
In this context, it is unknown whether ectonucleotidases CD39 and CD73, which are involved in the production of adenosine (Ado) that suppresses the specific antitumor immune response, are present in precursor lesions of CeCa.
In this pilot study, we analyzed the presence of CD39 and CD73 and their capacity to generate Ado in 25 cervical samples from patients with grade 1 cervical intraepithelial neoplasms (CIN-1) and 25 samples from normal donors (NDs) free of HPV infection.
Cells obtained from cervical samples of CIN-1 patients positive for HPV-16 showed higher CD39 and CD73 contents compared to samples obtained from CIN-1 patients negative for HPV-16 and NDs.
Interestingly, solubilized cervical mucus from these patients also showed higher contents of soluble CD39 and CD73, which were associated with a greater capacity to produce Ado from the hydrolysis of adenosine triphosphate (ATP) and adenosine monophosphate (AMP).
In addition, serum samples of these patients showed higher levels of TGF-β than those of CIN-1 patients negative for HPV-16 and ND.
These results suggest that persistent infection with HR-HPV, mostly HPV-16, in CIN-1 patients may promote the expression of CD39 and CD73 through the production of TGF-β in precursor lesions to generate an immunosuppressive microenvironment and allow its progression to CeCa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Lourdes Mora-García, María& López-Cisneros, Sofía& Gutiérrez-Serrano, Vianey& García-Rocha, Rosario& Weiss-Steider, Benny& Hernández-Montes, Jorge…[et al.]. 2019. HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Lourdes Mora-García, María…[et al.]. HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1. Mediators of Inflammation No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1192869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Lourdes Mora-García, María& López-Cisneros, Sofía& Gutiérrez-Serrano, Vianey& García-Rocha, Rosario& Weiss-Steider, Benny& Hernández-Montes, Jorge…[et al.]. HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر