HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1
Joint Authors
Chacon-Salinas, Rommel
Monroy-García, A.
Vallejo-Castillo, Luis
Weiss-Steider, Benny
de Lourdes Mora-García, María
López-Cisneros, Sofía
Gutiérrez-Serrano, Vianey
García-Rocha, Rosario
Hernández-Montes, Jorge
Sánchez-Peña, Héctor I.
Ávila-Ibarra, Luis Roberto
Don-López, Christian Azucena
Muñóz-Godínez, Ricardo
Pineda, Daniela Berenice Torres
Pérez-Tapia, Sonia Mayra
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The development of cervical cancer (CeCa) is associated with high-risk human papilloma virus (HR-HPV) infections, mainly HPV-16, which is present in more than 50% of cases.
The presence of immunosuppressive factors in the early stages of the disease is also strongly linked to CeCa progression.
In this context, it is unknown whether ectonucleotidases CD39 and CD73, which are involved in the production of adenosine (Ado) that suppresses the specific antitumor immune response, are present in precursor lesions of CeCa.
In this pilot study, we analyzed the presence of CD39 and CD73 and their capacity to generate Ado in 25 cervical samples from patients with grade 1 cervical intraepithelial neoplasms (CIN-1) and 25 samples from normal donors (NDs) free of HPV infection.
Cells obtained from cervical samples of CIN-1 patients positive for HPV-16 showed higher CD39 and CD73 contents compared to samples obtained from CIN-1 patients negative for HPV-16 and NDs.
Interestingly, solubilized cervical mucus from these patients also showed higher contents of soluble CD39 and CD73, which were associated with a greater capacity to produce Ado from the hydrolysis of adenosine triphosphate (ATP) and adenosine monophosphate (AMP).
In addition, serum samples of these patients showed higher levels of TGF-β than those of CIN-1 patients negative for HPV-16 and ND.
These results suggest that persistent infection with HR-HPV, mostly HPV-16, in CIN-1 patients may promote the expression of CD39 and CD73 through the production of TGF-β in precursor lesions to generate an immunosuppressive microenvironment and allow its progression to CeCa.
American Psychological Association (APA)
de Lourdes Mora-García, María& López-Cisneros, Sofía& Gutiérrez-Serrano, Vianey& García-Rocha, Rosario& Weiss-Steider, Benny& Hernández-Montes, Jorge…[et al.]. 2019. HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192869
Modern Language Association (MLA)
de Lourdes Mora-García, María…[et al.]. HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1. Mediators of Inflammation No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1192869
American Medical Association (AMA)
de Lourdes Mora-García, María& López-Cisneros, Sofía& Gutiérrez-Serrano, Vianey& García-Rocha, Rosario& Weiss-Steider, Benny& Hernández-Montes, Jorge…[et al.]. HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192869