Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People
المؤلفون المشاركون
Chen, Yue
Yang, Yu
Xiao, Peng-Lei
Yang, Ya
Gao, Jian-Chuan
Shi, Yan
Cheng, Wan-Ting
Song, Xiu-Xia
Jiang, Qing-Wu
Zhou, Yi-Biao
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To explore the association between infections with HIV and Schistosoma japonicum, and to determine the influences of the HIV-S.
japonicum coinfections on the immune system of Yi people.
Methods.
A block design study was conducted in a Yi county in southwestern China, one of the endemic areas of both HIV/AIDS and S.
japonicum in China.
All participants were screened for HIV antibodies and S.
japonicum antibodies (SjAb) and were classified into four groups: HIV(+)/S.
japonicum(−), HIV(−)/S.
japonicum (+), HIV(+)/S.
japonicum(+), and HIV(−)/S.
japonicum(−).
Results.
There were significant differences among the four groups in both CD4+ T lymphocytes and CD8+ T lymphocytes, but no significant difference in CD3+ T lymphocytes.
Both the CD4+ T lymphocyte counts and the ratio of CD4+/CD8+ were lower in HIV-infected people compared with those uninfected.
People infected with S.
japonicum had increased CD4+ T lymphocyte counts but reduced CD8+ T lymphocyte counts.
Similarly, the ratio of CD4+/CD8+ was higher in S.
japonicum-infected people compared with those uninfected.
People coinfected with HIV and S.
japonicum had lower CD4+ T lymphocyte counts, lower ratio of CD4+/CD8+, and higher CD8+ T lymphocyte counts compared with those infected with HIV only or S.
japonicum only.
People infected with HIV only and those coinfected with HIV and S.
japonicum had a higher level of IFN-γ compared with people with no infection.
There were no significant differences between people infected with HIV only and with S.
japonicum only in the levels of IFN-γ and IL-10.
Conclusions.
People coinfected with HIV and S.
japonicum might have a suppressed immune function because of a decrease in CD4+ T lymphocyte counts, a lowered ratio of CD4+/CD8+, and an increase in CD8+ T lymphocyte counts.
Coinfection with HIV and S.
japonicum would alter the level of IFN-γ in plasma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Yu& Xiao, Peng-Lei& Yang, Ya& Gao, Jian-Chuan& Shi, Yan& Cheng, Wan-Ting…[et al.]. 2018. Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192910
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Yu…[et al.]. Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1192910
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Yu& Xiao, Peng-Lei& Yang, Ya& Gao, Jian-Chuan& Shi, Yan& Cheng, Wan-Ting…[et al.]. Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192910
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192910
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر