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Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People
Joint Authors
Chen, Yue
Yang, Yu
Xiao, Peng-Lei
Yang, Ya
Gao, Jian-Chuan
Shi, Yan
Cheng, Wan-Ting
Song, Xiu-Xia
Jiang, Qing-Wu
Zhou, Yi-Biao
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To explore the association between infections with HIV and Schistosoma japonicum, and to determine the influences of the HIV-S.
japonicum coinfections on the immune system of Yi people.
Methods.
A block design study was conducted in a Yi county in southwestern China, one of the endemic areas of both HIV/AIDS and S.
japonicum in China.
All participants were screened for HIV antibodies and S.
japonicum antibodies (SjAb) and were classified into four groups: HIV(+)/S.
japonicum(−), HIV(−)/S.
japonicum (+), HIV(+)/S.
japonicum(+), and HIV(−)/S.
japonicum(−).
Results.
There were significant differences among the four groups in both CD4+ T lymphocytes and CD8+ T lymphocytes, but no significant difference in CD3+ T lymphocytes.
Both the CD4+ T lymphocyte counts and the ratio of CD4+/CD8+ were lower in HIV-infected people compared with those uninfected.
People infected with S.
japonicum had increased CD4+ T lymphocyte counts but reduced CD8+ T lymphocyte counts.
Similarly, the ratio of CD4+/CD8+ was higher in S.
japonicum-infected people compared with those uninfected.
People coinfected with HIV and S.
japonicum had lower CD4+ T lymphocyte counts, lower ratio of CD4+/CD8+, and higher CD8+ T lymphocyte counts compared with those infected with HIV only or S.
japonicum only.
People infected with HIV only and those coinfected with HIV and S.
japonicum had a higher level of IFN-γ compared with people with no infection.
There were no significant differences between people infected with HIV only and with S.
japonicum only in the levels of IFN-γ and IL-10.
Conclusions.
People coinfected with HIV and S.
japonicum might have a suppressed immune function because of a decrease in CD4+ T lymphocyte counts, a lowered ratio of CD4+/CD8+, and an increase in CD8+ T lymphocyte counts.
Coinfection with HIV and S.
japonicum would alter the level of IFN-γ in plasma.
American Psychological Association (APA)
Yang, Yu& Xiao, Peng-Lei& Yang, Ya& Gao, Jian-Chuan& Shi, Yan& Cheng, Wan-Ting…[et al.]. 2018. Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192910
Modern Language Association (MLA)
Yang, Yu…[et al.]. Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1192910
American Medical Association (AMA)
Yang, Yu& Xiao, Peng-Lei& Yang, Ya& Gao, Jian-Chuan& Shi, Yan& Cheng, Wan-Ting…[et al.]. Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192910