Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis
المؤلفون المشاركون
Shi, Guixiu
He, Yan
Wang, Dashan
Zhou, Mi
Lv, Xiuying
Song, Lina
Zhang, Di
Wang, Mian
Zhao, Xue
Yuan, Xiaoqing
Li, Yan
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in the pathogenesis of rheumatoid arthritis (RA).
However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial.
Those conflicting results may be caused by sample size, medication, and age- and sex-matched controls.
The aim of this study is to investigate the expression and activity of class I HDACs (1–3.8) and their effects on histone acetylation in peripheral blood mononuclear cells (PBMCs) from RA patients.
The expression of class I HDACs in PBMCs from RA patients was decreased in both mRNA and protein levels in comparison with HCs.
The nuclear HAT activities were dramatically increased.
Further, we found HDAC3 activity to be the most significantly reduced in overall reduction of HDACs in the RA group.
The extent of total histone H3, but not H4, acetylation in PBMCs from RA patients was increased compared to that in healthy controls (HCs) (p<0.01).
In RA PBMCs, the activity and expression of class I HDACs are decreased, which is accompanied with enhanced HAT activity.
An altered balance between HDAC and HAT activity was found in RA PBMCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yan& Zhou, Mi& Lv, Xiuying& Song, Lina& Zhang, Di& He, Yan…[et al.]. 2018. Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192944
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yan…[et al.]. Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192944
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yan& Zhou, Mi& Lv, Xiuying& Song, Lina& Zhang, Di& He, Yan…[et al.]. Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192944
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192944
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر