Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis
Joint Authors
Shi, Guixiu
He, Yan
Wang, Dashan
Zhou, Mi
Lv, Xiuying
Song, Lina
Zhang, Di
Wang, Mian
Zhao, Xue
Yuan, Xiaoqing
Li, Yan
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in the pathogenesis of rheumatoid arthritis (RA).
However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial.
Those conflicting results may be caused by sample size, medication, and age- and sex-matched controls.
The aim of this study is to investigate the expression and activity of class I HDACs (1–3.8) and their effects on histone acetylation in peripheral blood mononuclear cells (PBMCs) from RA patients.
The expression of class I HDACs in PBMCs from RA patients was decreased in both mRNA and protein levels in comparison with HCs.
The nuclear HAT activities were dramatically increased.
Further, we found HDAC3 activity to be the most significantly reduced in overall reduction of HDACs in the RA group.
The extent of total histone H3, but not H4, acetylation in PBMCs from RA patients was increased compared to that in healthy controls (HCs) (p<0.01).
In RA PBMCs, the activity and expression of class I HDACs are decreased, which is accompanied with enhanced HAT activity.
An altered balance between HDAC and HAT activity was found in RA PBMCs.
American Psychological Association (APA)
Li, Yan& Zhou, Mi& Lv, Xiuying& Song, Lina& Zhang, Di& He, Yan…[et al.]. 2018. Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192944
Modern Language Association (MLA)
Li, Yan…[et al.]. Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192944
American Medical Association (AMA)
Li, Yan& Zhou, Mi& Lv, Xiuying& Song, Lina& Zhang, Di& He, Yan…[et al.]. Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192944