New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity
المؤلفون المشاركون
Huang, Yu-Jhen
Lin, Chieh-Hsin
Lane, Hsien-Yuan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Major depressive disorder is a severe and complex mental disorder.
Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression.
Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain the whole picture of depressive disorders.
In this review, we discussed new treatment directions of depression, including modulation of glutamatergic system and noninvasive brain stimulation.
Dysfunction of glutamatergic neurotransmission plays an important role in the pathophysiology of depression.
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has rapid and lasting antidepressive effects in previous studies.
In addition to ketamine, other glutamatergic modulators, such as sarcosine, also show potential antidepressant effect in animal models or clinical trials.
Noninvasive brain stimulation is another new treatment strategy beyond pharmacotherapy.
Growing evidence has demonstrated that superficial brain stimulations, such as transcranial magnetic stimulation, transcranial direct current stimulation, cranial electrotherapy stimulation, and magnetic seizure therapy, can improve depressive symptoms.
The antidepressive effect of these brain stimulations may be through modulating neuroplasticity.
In conclusion, drugs that modulate neurotransmission via NMDA receptor and noninvasive brain stimulation may provide new directions of treatment for depression.
Furthermore, exploring the underlying mechanisms will help in developing novel therapies for depression in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Yu-Jhen& Lane, Hsien-Yuan& Lin, Chieh-Hsin. 2017. New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity. Neural Plasticity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Yu-Jhen…[et al.]. New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity. Neural Plasticity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1193018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Yu-Jhen& Lane, Hsien-Yuan& Lin, Chieh-Hsin. New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر