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New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity
Joint Authors
Huang, Yu-Jhen
Lin, Chieh-Hsin
Lane, Hsien-Yuan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Major depressive disorder is a severe and complex mental disorder.
Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression.
Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain the whole picture of depressive disorders.
In this review, we discussed new treatment directions of depression, including modulation of glutamatergic system and noninvasive brain stimulation.
Dysfunction of glutamatergic neurotransmission plays an important role in the pathophysiology of depression.
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has rapid and lasting antidepressive effects in previous studies.
In addition to ketamine, other glutamatergic modulators, such as sarcosine, also show potential antidepressant effect in animal models or clinical trials.
Noninvasive brain stimulation is another new treatment strategy beyond pharmacotherapy.
Growing evidence has demonstrated that superficial brain stimulations, such as transcranial magnetic stimulation, transcranial direct current stimulation, cranial electrotherapy stimulation, and magnetic seizure therapy, can improve depressive symptoms.
The antidepressive effect of these brain stimulations may be through modulating neuroplasticity.
In conclusion, drugs that modulate neurotransmission via NMDA receptor and noninvasive brain stimulation may provide new directions of treatment for depression.
Furthermore, exploring the underlying mechanisms will help in developing novel therapies for depression in the future.
American Psychological Association (APA)
Huang, Yu-Jhen& Lane, Hsien-Yuan& Lin, Chieh-Hsin. 2017. New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity. Neural Plasticity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193018
Modern Language Association (MLA)
Huang, Yu-Jhen…[et al.]. New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity. Neural Plasticity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1193018
American Medical Association (AMA)
Huang, Yu-Jhen& Lane, Hsien-Yuan& Lin, Chieh-Hsin. New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193018