Total HLA Class I Antigen Loss with the Downregulation of Antigen-Processing Machinery Components in Two Newly Established Sarcomatoid Hepatocellular Carcinoma Cell Lines
المؤلفون المشاركون
Chen, Chien-Lin
Lei, Wei-Yi
Hsiung, Shih-Chieh
Wen, Shao-Hsuan
Hsieh, Chin-Hsuan
Chang, Chien-Chung
Liao, Shuen-Kuei
Wallace, Christopher Glenn
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Limited information is currently available concerning HLA class I antigen abnormalities in sarcomatoid hepatocellular carcinoma (sHCC).
Here, we have analyzed the growth characteristics and HLA class I antigen status of four sHCC cell lines (sHCC29, sHCC63, sHCC74, and SAR-HCV); the first three were newly established in this study.
Among the four, sHCC29 showed the highest growth rate in vitro and tumorigenicity in NOD-SCID mice.
Unlike sHCC74 and SAR-HCV, both sHCC29 and sHCC63 had no detectable surface HLA class I antigen expression, alongside undetected intracellular β2-microglobulin (β2m) and marked HLA class I heavy chain and selective antigen-processing machinery (APM) component downregulation.
The loss of β2m in sHCC29 and sHCC63 was caused by a >49 kb deletion across the B2M locus, while their downregulation of APM components was transcriptional, reversible by IFN-γ only in several components.
β2m was also undetected in the primary HCC lesions of the patients involved, indicating its in vivo relevance.
We report for the first time HLA class I antigen loss with underlying B2M gene deficiency and APM defects in 50% (2 of 4) of the sHCC cell lines tested.
These findings may have implications for a proper design of T cell immunotherapy for the treatment of sHCC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lei, Wei-Yi& Hsiung, Shih-Chieh& Wen, Shao-Hsuan& Hsieh, Chin-Hsuan& Chen, Chien-Lin& Wallace, Christopher Glenn…[et al.]. 2018. Total HLA Class I Antigen Loss with the Downregulation of Antigen-Processing Machinery Components in Two Newly Established Sarcomatoid Hepatocellular Carcinoma Cell Lines. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193092
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lei, Wei-Yi…[et al.]. Total HLA Class I Antigen Loss with the Downregulation of Antigen-Processing Machinery Components in Two Newly Established Sarcomatoid Hepatocellular Carcinoma Cell Lines. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1193092
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lei, Wei-Yi& Hsiung, Shih-Chieh& Wen, Shao-Hsuan& Hsieh, Chin-Hsuan& Chen, Chien-Lin& Wallace, Christopher Glenn…[et al.]. Total HLA Class I Antigen Loss with the Downregulation of Antigen-Processing Machinery Components in Two Newly Established Sarcomatoid Hepatocellular Carcinoma Cell Lines. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1193092
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193092
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر