Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells
المؤلفون المشاركون
Zhou, Jia
Hu, Mengyao
Li, Jie
Liu, Yan
Luo, Jialiang
Zhang, Liyun
Lu, Xiao
Zuo, Daming
Chen, Zhengliang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Natural killer (NK) cells represent the founding members of innate lymphoid cells (ILC) and play critical roles in inflammation and the immune response.
NK cell effector functions are regulated and fine-tuned by various immune modulators.
Mannan (or mannose)-binding lectin (MBL), a soluble C-type lectin, is traditionally recognized as an initiator of the complement pathway.
Recently, it is also considered as an immunomodulator by its interaction with kinds of immune cells.
However, the effect of MBL on NK cell function remains unexplored.
In this study, we found that human plasma MBL could interact directly with peripheral NK cells partially via its collagen-like region (CLR).
This MBL binding markedly suppressed the interleukin-2- (IL-2-) induced inflammatory cytokine tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) production but increased the IL-10 production in NK cells.
In addition, the expression of activation surface markers such as CD25 and CD69 declined after MBL treatment.
Also, MBL impaired the proliferation and lymphokine-activated killing (LAK) of NK cells.
Moreover, we demonstrated that MBL inhibited IL-2-induced signal transducers and activators of transcription 5 (STAT5) activation in NK cells.
In conclusion, we have uncovered a far unknown regulatory role of MBL on NK cells, a new clue that could be important in the immunomodulatory networks of immune responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Jia& Hu, Mengyao& Li, Jie& Liu, Yan& Luo, Jialiang& Zhang, Liyun…[et al.]. 2019. Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Jia…[et al.]. Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1193157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Jia& Hu, Mengyao& Li, Jie& Liu, Yan& Luo, Jialiang& Zhang, Liyun…[et al.]. Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر