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Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells
Joint Authors
Zhou, Jia
Hu, Mengyao
Li, Jie
Liu, Yan
Luo, Jialiang
Zhang, Liyun
Lu, Xiao
Zuo, Daming
Chen, Zhengliang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Natural killer (NK) cells represent the founding members of innate lymphoid cells (ILC) and play critical roles in inflammation and the immune response.
NK cell effector functions are regulated and fine-tuned by various immune modulators.
Mannan (or mannose)-binding lectin (MBL), a soluble C-type lectin, is traditionally recognized as an initiator of the complement pathway.
Recently, it is also considered as an immunomodulator by its interaction with kinds of immune cells.
However, the effect of MBL on NK cell function remains unexplored.
In this study, we found that human plasma MBL could interact directly with peripheral NK cells partially via its collagen-like region (CLR).
This MBL binding markedly suppressed the interleukin-2- (IL-2-) induced inflammatory cytokine tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) production but increased the IL-10 production in NK cells.
In addition, the expression of activation surface markers such as CD25 and CD69 declined after MBL treatment.
Also, MBL impaired the proliferation and lymphokine-activated killing (LAK) of NK cells.
Moreover, we demonstrated that MBL inhibited IL-2-induced signal transducers and activators of transcription 5 (STAT5) activation in NK cells.
In conclusion, we have uncovered a far unknown regulatory role of MBL on NK cells, a new clue that could be important in the immunomodulatory networks of immune responses.
American Psychological Association (APA)
Zhou, Jia& Hu, Mengyao& Li, Jie& Liu, Yan& Luo, Jialiang& Zhang, Liyun…[et al.]. 2019. Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193157
Modern Language Association (MLA)
Zhou, Jia…[et al.]. Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1193157
American Medical Association (AMA)
Zhou, Jia& Hu, Mengyao& Li, Jie& Liu, Yan& Luo, Jialiang& Zhang, Liyun…[et al.]. Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193157