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Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism
المؤلفون المشاركون
Ghirardi, Mirella
Tempia, F.
Hoxha, Eriola
Lippiello, Pellegrino
Miniaci, Maria Concetta
Scelfo, Bibiana
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-15
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms.
The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plasticity mechanisms underlying the formation of new synapses and retraction of redundant ones.
For the attainment of the monoinnervation of the Purkinje cell by a single climbing fiber, several signals are involved, including electrical activity, contact signals, homosynaptic and heterosynaptic interaction, calcium transients, postsynaptic receptors, and transduction pathways.
An important role in this developmental program is played by serotonergic projections that, acting on temporally and spatially regulated postsynaptic receptors, induce and modulate the phases of synaptic formation and maturation.
In the adult cerebellar cortex, many developmental mechanisms persist but play different roles, such as supporting synaptic plasticity during learning and formation of cerebellar memory traces.
A dysfunction at any stage of this process can lead to disorders of cerebellar origin, which include autism spectrum disorders but are not limited to motor deficits.
Recent evidence in animal models links impairment of Purkinje cell function with autism-like symptoms including sociability deficits, stereotyped movements, and interspecific communication by vocalization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hoxha, Eriola& Lippiello, Pellegrino& Scelfo, Bibiana& Tempia, F.& Ghirardi, Mirella& Miniaci, Maria Concetta. 2017. Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism. Neural Plasticity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193158
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hoxha, Eriola…[et al.]. Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism. Neural Plasticity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1193158
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hoxha, Eriola& Lippiello, Pellegrino& Scelfo, Bibiana& Tempia, F.& Ghirardi, Mirella& Miniaci, Maria Concetta. Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193158
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193158
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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