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Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism
Joint Authors
Ghirardi, Mirella
Tempia, F.
Hoxha, Eriola
Lippiello, Pellegrino
Miniaci, Maria Concetta
Scelfo, Bibiana
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms.
The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the structural plasticity mechanisms underlying the formation of new synapses and retraction of redundant ones.
For the attainment of the monoinnervation of the Purkinje cell by a single climbing fiber, several signals are involved, including electrical activity, contact signals, homosynaptic and heterosynaptic interaction, calcium transients, postsynaptic receptors, and transduction pathways.
An important role in this developmental program is played by serotonergic projections that, acting on temporally and spatially regulated postsynaptic receptors, induce and modulate the phases of synaptic formation and maturation.
In the adult cerebellar cortex, many developmental mechanisms persist but play different roles, such as supporting synaptic plasticity during learning and formation of cerebellar memory traces.
A dysfunction at any stage of this process can lead to disorders of cerebellar origin, which include autism spectrum disorders but are not limited to motor deficits.
Recent evidence in animal models links impairment of Purkinje cell function with autism-like symptoms including sociability deficits, stereotyped movements, and interspecific communication by vocalization.
American Psychological Association (APA)
Hoxha, Eriola& Lippiello, Pellegrino& Scelfo, Bibiana& Tempia, F.& Ghirardi, Mirella& Miniaci, Maria Concetta. 2017. Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism. Neural Plasticity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193158
Modern Language Association (MLA)
Hoxha, Eriola…[et al.]. Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism. Neural Plasticity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1193158
American Medical Association (AMA)
Hoxha, Eriola& Lippiello, Pellegrino& Scelfo, Bibiana& Tempia, F.& Ghirardi, Mirella& Miniaci, Maria Concetta. Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193158