IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice
المؤلفون المشاركون
Tong, Zhao-Hui
Qian, XiaoJun
Rong, Heng-Mo
Zhang, Chao
Li, Ting
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Pneumocystis pneumonia (PCP) remains a common opportunistic infection in immunosuppressed individuals.
Current studies showed that multiple immune cells and cytokines took part in the host defense against Pneumocystis (PC).
However, the roles of IL-17 and IL-10 in the development of PCP have not been elucidated.
Methods.
IL-10 and IL-17 levels in serum from PCP mice were detected via ELISA.
The percentages of B10 cells, IL-10+ macrophages, and IL-10+ T cells in the lung from IL-17–/– PCP mice and Th17 cells and IL-17+ γδT cells in IL-10–/– PCP mice were examined via flow cytometry.
Also, antibody neutralization examination was also performed to elucidate the relationship of IL-17 and IL-10 in the PCP model.
Results.
We noted the increase of IL-17 and IL-10 levels in serum from mice infected with Pneumocystis.
Furthermore, deficiency of IL-17 or IL-10 could lead to the delayed clearance of Pneumocystis and more severed lung damage.
Our data also demonstrated that IL-17 deficiency enhanced the serum IL-10 level and the percentages of B10 cells, IL-10+ macrophages, and IL-10+ T cells in the lung from PCP mice.
Interestingly, we also noted an increase of the IL-17 level in serum and Th17 cell and IL-17+ γδT cell percentages in the lung from IL-10–/– PCP mice.
Using antibody neutralization experiments, we found that the STAT3 gene might play a critical role in the interplay of IL-17 and IL-10 in PCP.
Conclusion.
Taken together, our results demonstrated that IL-17 and IL-10 could play the protective roles in the progression of PCP and the inverse correlation of them might be mediated by STAT3.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rong, Heng-Mo& Qian, XiaoJun& Zhang, Chao& Li, Ting& Tong, Zhao-Hui. 2019. IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193160
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rong, Heng-Mo…[et al.]. IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1193160
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rong, Heng-Mo& Qian, XiaoJun& Zhang, Chao& Li, Ting& Tong, Zhao-Hui. IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193160
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193160
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر