IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice
Joint Authors
Tong, Zhao-Hui
Qian, XiaoJun
Rong, Heng-Mo
Zhang, Chao
Li, Ting
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Pneumocystis pneumonia (PCP) remains a common opportunistic infection in immunosuppressed individuals.
Current studies showed that multiple immune cells and cytokines took part in the host defense against Pneumocystis (PC).
However, the roles of IL-17 and IL-10 in the development of PCP have not been elucidated.
Methods.
IL-10 and IL-17 levels in serum from PCP mice were detected via ELISA.
The percentages of B10 cells, IL-10+ macrophages, and IL-10+ T cells in the lung from IL-17–/– PCP mice and Th17 cells and IL-17+ γδT cells in IL-10–/– PCP mice were examined via flow cytometry.
Also, antibody neutralization examination was also performed to elucidate the relationship of IL-17 and IL-10 in the PCP model.
Results.
We noted the increase of IL-17 and IL-10 levels in serum from mice infected with Pneumocystis.
Furthermore, deficiency of IL-17 or IL-10 could lead to the delayed clearance of Pneumocystis and more severed lung damage.
Our data also demonstrated that IL-17 deficiency enhanced the serum IL-10 level and the percentages of B10 cells, IL-10+ macrophages, and IL-10+ T cells in the lung from PCP mice.
Interestingly, we also noted an increase of the IL-17 level in serum and Th17 cell and IL-17+ γδT cell percentages in the lung from IL-10–/– PCP mice.
Using antibody neutralization experiments, we found that the STAT3 gene might play a critical role in the interplay of IL-17 and IL-10 in PCP.
Conclusion.
Taken together, our results demonstrated that IL-17 and IL-10 could play the protective roles in the progression of PCP and the inverse correlation of them might be mediated by STAT3.
American Psychological Association (APA)
Rong, Heng-Mo& Qian, XiaoJun& Zhang, Chao& Li, Ting& Tong, Zhao-Hui. 2019. IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193160
Modern Language Association (MLA)
Rong, Heng-Mo…[et al.]. IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1193160
American Medical Association (AMA)
Rong, Heng-Mo& Qian, XiaoJun& Zhang, Chao& Li, Ting& Tong, Zhao-Hui. IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193160