Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells
المؤلفون المشاركون
Bin, Bum-Ho
Seo, Juyeon
Kim, Sung Tae
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Zinc is an important trace metal in immune systems, and zinc transporters are involved in many immune responses.
Recent advances have revealed the structural and biochemical bases for zinc transport across the cell membrane, with clinical implications for the regulation of zinc homeostasis in immune cells like dendritic cells, T cells, B cells, and mast cells.
In this review, we discuss the function, structure, and transport aspects of two major mammalian zinc transporter types, importers and exporters.
First, Zrt-/Irt-like proteins (ZIPs) mediate the zinc influx from the extracellular or luminal side into the cytoplasm.
There are 14 ZIP family members in humans.
They form a homo- or heterodimer with 8 transmembrane domains and extra-/intracellular domains of various lengths.
Several ZIP members show specific extracellular domains composed of two subdomains, a helix-rich domain and proline-alanine-leucine (PAL) motif-containing domain.
Second, ZnT (zinc transporter) was initially identified in early studies of zinc biology; it mediates zinc efflux as a counterpart of ZIPs in zinc homeostasis.
Ten family members have been identified.
They show a unique architecture characterized by a Y-shaped conformation and a large cytoplasmic domain.
A precise, comprehensive understanding of the structures and transport mechanisms of ZIP and ZnT in combination with mice experiments would provide promising drug targets as well as a basis for identifying other transporters with therapeutic potential.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bin, Bum-Ho& Seo, Juyeon& Kim, Sung Tae. 2018. Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193293
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bin, Bum-Ho…[et al.]. Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1193293
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bin, Bum-Ho& Seo, Juyeon& Kim, Sung Tae. Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193293
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193293
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر