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Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells
Joint Authors
Bin, Bum-Ho
Seo, Juyeon
Kim, Sung Tae
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Zinc is an important trace metal in immune systems, and zinc transporters are involved in many immune responses.
Recent advances have revealed the structural and biochemical bases for zinc transport across the cell membrane, with clinical implications for the regulation of zinc homeostasis in immune cells like dendritic cells, T cells, B cells, and mast cells.
In this review, we discuss the function, structure, and transport aspects of two major mammalian zinc transporter types, importers and exporters.
First, Zrt-/Irt-like proteins (ZIPs) mediate the zinc influx from the extracellular or luminal side into the cytoplasm.
There are 14 ZIP family members in humans.
They form a homo- or heterodimer with 8 transmembrane domains and extra-/intracellular domains of various lengths.
Several ZIP members show specific extracellular domains composed of two subdomains, a helix-rich domain and proline-alanine-leucine (PAL) motif-containing domain.
Second, ZnT (zinc transporter) was initially identified in early studies of zinc biology; it mediates zinc efflux as a counterpart of ZIPs in zinc homeostasis.
Ten family members have been identified.
They show a unique architecture characterized by a Y-shaped conformation and a large cytoplasmic domain.
A precise, comprehensive understanding of the structures and transport mechanisms of ZIP and ZnT in combination with mice experiments would provide promising drug targets as well as a basis for identifying other transporters with therapeutic potential.
American Psychological Association (APA)
Bin, Bum-Ho& Seo, Juyeon& Kim, Sung Tae. 2018. Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193293
Modern Language Association (MLA)
Bin, Bum-Ho…[et al.]. Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1193293
American Medical Association (AMA)
Bin, Bum-Ho& Seo, Juyeon& Kim, Sung Tae. Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1193293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193293