Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas
المؤلفون المشاركون
Acevedo-Triana, C. A.
León, L. A.
Cardenas, F. P.
المصدر
Neurology Research International
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Brain atlases are tools based on comprehensive studies used to locate biological characteristics (structures, connections, proteins, and gene expression) in different regions of the brain.
These atlases have been disseminated to the point where tools have been created to store, manage, and share the information they contain.
This study used the data published by the Allen Mouse Brain Atlas (2004) for mice (C57BL/6J) and Allen Human Brain Atlas (2010) for humans (6 donors) to compare the expression of serotonin-related genes.
Genes of interest were searched for manually in each case (in situ hybridization for mice and microarrays for humans), normalized expression data (z-scores) were extracted, and the results were graphed.
Despite the differences in methodology, quantification, and subjects used in the process, a high degree of similarity was found between expression data.
Here we compare expression in a way that allows the use of translational research methods to infer and validate knowledge.
This type of study allows part of the relationship between structures and functions to be identified, by examining expression patterns and comparing levels of expression in different states, anatomical correlations, and phenotypes between different species.
The study concludes by discussing the importance of knowing, managing, and disseminating comprehensive, open-access studies in neuroscience.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Acevedo-Triana, C. A.& León, L. A.& Cardenas, F. P.. 2017. Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas. Neurology Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Acevedo-Triana, C. A.…[et al.]. Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas. Neurology Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1193421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Acevedo-Triana, C. A.& León, L. A.& Cardenas, F. P.. Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas. Neurology Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر