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Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas
Joint Authors
Acevedo-Triana, C. A.
León, L. A.
Cardenas, F. P.
Source
Neurology Research International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Brain atlases are tools based on comprehensive studies used to locate biological characteristics (structures, connections, proteins, and gene expression) in different regions of the brain.
These atlases have been disseminated to the point where tools have been created to store, manage, and share the information they contain.
This study used the data published by the Allen Mouse Brain Atlas (2004) for mice (C57BL/6J) and Allen Human Brain Atlas (2010) for humans (6 donors) to compare the expression of serotonin-related genes.
Genes of interest were searched for manually in each case (in situ hybridization for mice and microarrays for humans), normalized expression data (z-scores) were extracted, and the results were graphed.
Despite the differences in methodology, quantification, and subjects used in the process, a high degree of similarity was found between expression data.
Here we compare expression in a way that allows the use of translational research methods to infer and validate knowledge.
This type of study allows part of the relationship between structures and functions to be identified, by examining expression patterns and comparing levels of expression in different states, anatomical correlations, and phenotypes between different species.
The study concludes by discussing the importance of knowing, managing, and disseminating comprehensive, open-access studies in neuroscience.
American Psychological Association (APA)
Acevedo-Triana, C. A.& León, L. A.& Cardenas, F. P.. 2017. Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas. Neurology Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193421
Modern Language Association (MLA)
Acevedo-Triana, C. A.…[et al.]. Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas. Neurology Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1193421
American Medical Association (AMA)
Acevedo-Triana, C. A.& León, L. A.& Cardenas, F. P.. Comparing the Expression of Genes Related to Serotonin (5-HT) in C57BL6J Mice and Humans Based on Data Available at the Allen Mouse Brain Atlas and Allen Human Brain Atlas. Neurology Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1193421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193421