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IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome
المؤلفون المشاركون
Zhu, Ruirui
Mao, Xiaobo
Zhang, Fangyuan
Zhong, Yucheng
Yu, Kunwu
Wei, Yuzhen
Sun, Haitao
Xu, Wenbin
Luo, Quan
Wang, Yue
Ding, Yan
Zeng, Qiu-tang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-09
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Interleukin-37 (IL-37) acts as an inhibitor of innate and adaptive immunity.
However, the exact role of IL-37 in the patients with acute coronary syndrome (ACS) remains to be elucidated.
Methods.
Patients were classified into 4 groups: normal coronary artery (NCA), stable angina (SA), unstable angina (UA), and acute myocardial infarction (AMI).
The circulating Treg, Th1, and Th17 frequencies were measured.
The effect of IL-37 on stimulated peripheral blood mononuclear cells (PBMCs) and the influence of IL-37 on DCs were explored.
In addition, the role of IL-37-treated tDCs on Treg cell expansion and the stability of these tDCs were also tested.
Results.
Our results showed that the circulating Treg frequencies were decreased, while Th1 and Th17 frequencies were increased in ACS patients, and that IL-37 expanded Tregs but suppressed Th1 and Th17 cells in activated PBMCs derived from ACS patients.
Of note, IL-37-treated human DCs obtained a tolerogenic phenotype, and such tDCs promoted expansion of Tregs and decreased the Th1 and Th17 populations when cocultured with CD4+ T cells.
Interestingly, IL-37-treated DCs from patients with ACS are phenotypically and functionally comparable to IL-37-treated DCs from NCA patients, and tolerogenic properties of IL-37-treated DCs were highly stable.
Conclusion.
In conclusion, our results reveal a beneficial role of IL-37 in the patients with ACS and suggest that autologous IL-37-treated tDCs may be a novel therapeutic strategy for the patients with ACS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mao, Xiaobo& Zhu, Ruirui& Zhang, Fangyuan& Zhong, Yucheng& Yu, Kunwu& Wei, Yuzhen…[et al.]. 2019. IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mao, Xiaobo…[et al.]. IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome. Mediators of Inflammation No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1193662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mao, Xiaobo& Zhu, Ruirui& Zhang, Fangyuan& Zhong, Yucheng& Yu, Kunwu& Wei, Yuzhen…[et al.]. IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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