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IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome
Joint Authors
Zhu, Ruirui
Mao, Xiaobo
Zhang, Fangyuan
Zhong, Yucheng
Yu, Kunwu
Wei, Yuzhen
Sun, Haitao
Xu, Wenbin
Luo, Quan
Wang, Yue
Ding, Yan
Zeng, Qiu-tang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Interleukin-37 (IL-37) acts as an inhibitor of innate and adaptive immunity.
However, the exact role of IL-37 in the patients with acute coronary syndrome (ACS) remains to be elucidated.
Methods.
Patients were classified into 4 groups: normal coronary artery (NCA), stable angina (SA), unstable angina (UA), and acute myocardial infarction (AMI).
The circulating Treg, Th1, and Th17 frequencies were measured.
The effect of IL-37 on stimulated peripheral blood mononuclear cells (PBMCs) and the influence of IL-37 on DCs were explored.
In addition, the role of IL-37-treated tDCs on Treg cell expansion and the stability of these tDCs were also tested.
Results.
Our results showed that the circulating Treg frequencies were decreased, while Th1 and Th17 frequencies were increased in ACS patients, and that IL-37 expanded Tregs but suppressed Th1 and Th17 cells in activated PBMCs derived from ACS patients.
Of note, IL-37-treated human DCs obtained a tolerogenic phenotype, and such tDCs promoted expansion of Tregs and decreased the Th1 and Th17 populations when cocultured with CD4+ T cells.
Interestingly, IL-37-treated DCs from patients with ACS are phenotypically and functionally comparable to IL-37-treated DCs from NCA patients, and tolerogenic properties of IL-37-treated DCs were highly stable.
Conclusion.
In conclusion, our results reveal a beneficial role of IL-37 in the patients with ACS and suggest that autologous IL-37-treated tDCs may be a novel therapeutic strategy for the patients with ACS.
American Psychological Association (APA)
Mao, Xiaobo& Zhu, Ruirui& Zhang, Fangyuan& Zhong, Yucheng& Yu, Kunwu& Wei, Yuzhen…[et al.]. 2019. IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193662
Modern Language Association (MLA)
Mao, Xiaobo…[et al.]. IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome. Mediators of Inflammation No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1193662
American Medical Association (AMA)
Mao, Xiaobo& Zhu, Ruirui& Zhang, Fangyuan& Zhong, Yucheng& Yu, Kunwu& Wei, Yuzhen…[et al.]. IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193662