The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport
المؤلفون المشاركون
Fisi, Viktória
Miseta, Attila
Nagy, Tamás
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
O-linked N-acetylglucosamine (O-GlcNAc) is a posttranslational modification that is increasingly recognized as a signal transduction mechanism.
Unlike other glycans, O-GlcNAc is a highly dynamic and reversible process that involves the addition and removal of a single N-acetylglucosamine molecule to Ser/Thr residues of proteins.
UDP-GlcNAc—the direct substrate for O-GlcNAc modification—is controlled by the rate of cellular metabolism, and thus O-GlcNAc is dependent on substrate availability.
Serving as a feedback mechanism, O-GlcNAc influences the regulation of insulin signaling and glucose transport.
Besides nutrient sensing, O-GlcNAc was also implicated in the regulation of various physiological and pathophysiological processes.
Due to improvements of mass spectrometry techniques, more than one thousand proteins were detected to carry the O-GlcNAc moiety; many of them are known to participate in the regulation of metabolites, ions, or protein transport across biological membranes.
Recent studies also indicated that O-GlcNAc is involved in stress adaptation; overwhelming evidences suggest that O-GlcNAc levels increase upon stress.
O-GlcNAc elevation is generally considered to be beneficial during stress, although the exact nature of its protective effect is not understood.
In this review, we summarize the current data regarding the oxidative stress-related changes of O-GlcNAc levels and discuss the implications related to membrane trafficking.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fisi, Viktória& Miseta, Attila& Nagy, Tamás. 2017. The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1193781
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fisi, Viktória…[et al.]. The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1193781
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fisi, Viktória& Miseta, Attila& Nagy, Tamás. The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1193781
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193781
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر