The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport
Joint Authors
Fisi, Viktória
Miseta, Attila
Nagy, Tamás
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
O-linked N-acetylglucosamine (O-GlcNAc) is a posttranslational modification that is increasingly recognized as a signal transduction mechanism.
Unlike other glycans, O-GlcNAc is a highly dynamic and reversible process that involves the addition and removal of a single N-acetylglucosamine molecule to Ser/Thr residues of proteins.
UDP-GlcNAc—the direct substrate for O-GlcNAc modification—is controlled by the rate of cellular metabolism, and thus O-GlcNAc is dependent on substrate availability.
Serving as a feedback mechanism, O-GlcNAc influences the regulation of insulin signaling and glucose transport.
Besides nutrient sensing, O-GlcNAc was also implicated in the regulation of various physiological and pathophysiological processes.
Due to improvements of mass spectrometry techniques, more than one thousand proteins were detected to carry the O-GlcNAc moiety; many of them are known to participate in the regulation of metabolites, ions, or protein transport across biological membranes.
Recent studies also indicated that O-GlcNAc is involved in stress adaptation; overwhelming evidences suggest that O-GlcNAc levels increase upon stress.
O-GlcNAc elevation is generally considered to be beneficial during stress, although the exact nature of its protective effect is not understood.
In this review, we summarize the current data regarding the oxidative stress-related changes of O-GlcNAc levels and discuss the implications related to membrane trafficking.
American Psychological Association (APA)
Fisi, Viktória& Miseta, Attila& Nagy, Tamás. 2017. The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1193781
Modern Language Association (MLA)
Fisi, Viktória…[et al.]. The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1193781
American Medical Association (AMA)
Fisi, Viktória& Miseta, Attila& Nagy, Tamás. The Role of Stress-Induced O-GlcNAc Protein Modification in the Regulation of Membrane Transport. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1193781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193781