Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project
المؤلفون المشاركون
Grune, Tilman
Weber, Daniela
Stuetz, Wolfgang
Toussaint, Olivier
Debacq-Chainiaux, Florence
Dollé, Martijn E. T.
Sikora, Ewa
Breusing, Nicolle
Sindlinger, Thilo
Moreno-Villanueva, María
Hervonen, Antti
Franceschi, Claudio
Bürkle, Alexander
Jansen, Eugene H. J. M.
Gonos, Efstathios S.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Oxidative stress and antioxidants play a role in age-related diseases and in the aging process.
We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE.
To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants.
These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses.
In addition, 683 middle-aged reference participants (35–54 years) served as a control.
After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups.
Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age.
Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group.
We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weber, Daniela& Stuetz, Wolfgang& Toussaint, Olivier& Debacq-Chainiaux, Florence& Dollé, Martijn E. T.& Jansen, Eugene H. J. M.…[et al.]. 2017. Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193801
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weber, Daniela…[et al.]. Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193801
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weber, Daniela& Stuetz, Wolfgang& Toussaint, Olivier& Debacq-Chainiaux, Florence& Dollé, Martijn E. T.& Jansen, Eugene H. J. M.…[et al.]. Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193801
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193801
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر