Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project
Joint Authors
Grune, Tilman
Weber, Daniela
Stuetz, Wolfgang
Toussaint, Olivier
Debacq-Chainiaux, Florence
Dollé, Martijn E. T.
Sikora, Ewa
Breusing, Nicolle
Sindlinger, Thilo
Moreno-Villanueva, María
Hervonen, Antti
Franceschi, Claudio
Bürkle, Alexander
Jansen, Eugene H. J. M.
Gonos, Efstathios S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Oxidative stress and antioxidants play a role in age-related diseases and in the aging process.
We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE.
To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants.
These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses.
In addition, 683 middle-aged reference participants (35–54 years) served as a control.
After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups.
Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age.
Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group.
We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.
American Psychological Association (APA)
Weber, Daniela& Stuetz, Wolfgang& Toussaint, Olivier& Debacq-Chainiaux, Florence& Dollé, Martijn E. T.& Jansen, Eugene H. J. M.…[et al.]. 2017. Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193801
Modern Language Association (MLA)
Weber, Daniela…[et al.]. Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193801
American Medical Association (AMA)
Weber, Daniela& Stuetz, Wolfgang& Toussaint, Olivier& Debacq-Chainiaux, Florence& Dollé, Martijn E. T.& Jansen, Eugene H. J. M.…[et al.]. Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193801