Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice
المؤلفون المشاركون
Shi, Xianqing
Fu, Yongjian
Zhang, SongSong
Ding, Hao
Chen, Jin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In subarachnoid hemorrhagic brain injury, the early crucial events are edema formation due to inflammatory responses and blood-brain barrier disruption.
Baicalin, a flavone glycoside, has antineuroinflammatory and antioxidant properties.
We examined the effect of baicalin in subarachnoid hemorrhagic brain injury.
Subarachnoid hemorrhage was induced through filament perforation and either baicalin or vehicle was administered 30 min prior to surgery.
Brain tissues were collected 24 hours after surgery after evaluation of neurological scores.
Brain tissues were processed for water content, real-time PCR, and immunoblot analyses.
Baicalin improved neurological score and brain water content.
Decreased levels of tight junction proteins (occludin, claudin-5, ZO-1, and collagen IV) required for blood-brain barrier function were restored to normal level by baicalin.
Real-time PCR data demonstrated that baicalin attenuated increased proinflammatory cytokine (IL-1β, IL-6, and CXCL-3) production in subarachnoid hemorrhage mice.
In addition to that, baicalin attenuated microglial cell secretion of IL-1β and IL-6 induced by lipopolysaccharide (100 ng/ml) dose dependently.
Finally, baicalin attenuated induction of NOS-2 and NOX-2 in SAH mice at the mRNA and protein level.
Thus, we demonstrated that baicalin inhibited microglial cell activation and reduced inflammation, oxidative damage, and brain edema.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Xianqing& Fu, Yongjian& Zhang, SongSong& Ding, Hao& Chen, Jin. 2017. Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193804
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Xianqing…[et al.]. Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1193804
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Xianqing& Fu, Yongjian& Zhang, SongSong& Ding, Hao& Chen, Jin. Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193804
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193804
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر