Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice
Joint Authors
Shi, Xianqing
Fu, Yongjian
Zhang, SongSong
Ding, Hao
Chen, Jin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In subarachnoid hemorrhagic brain injury, the early crucial events are edema formation due to inflammatory responses and blood-brain barrier disruption.
Baicalin, a flavone glycoside, has antineuroinflammatory and antioxidant properties.
We examined the effect of baicalin in subarachnoid hemorrhagic brain injury.
Subarachnoid hemorrhage was induced through filament perforation and either baicalin or vehicle was administered 30 min prior to surgery.
Brain tissues were collected 24 hours after surgery after evaluation of neurological scores.
Brain tissues were processed for water content, real-time PCR, and immunoblot analyses.
Baicalin improved neurological score and brain water content.
Decreased levels of tight junction proteins (occludin, claudin-5, ZO-1, and collagen IV) required for blood-brain barrier function were restored to normal level by baicalin.
Real-time PCR data demonstrated that baicalin attenuated increased proinflammatory cytokine (IL-1β, IL-6, and CXCL-3) production in subarachnoid hemorrhage mice.
In addition to that, baicalin attenuated microglial cell secretion of IL-1β and IL-6 induced by lipopolysaccharide (100 ng/ml) dose dependently.
Finally, baicalin attenuated induction of NOS-2 and NOX-2 in SAH mice at the mRNA and protein level.
Thus, we demonstrated that baicalin inhibited microglial cell activation and reduced inflammation, oxidative damage, and brain edema.
American Psychological Association (APA)
Shi, Xianqing& Fu, Yongjian& Zhang, SongSong& Ding, Hao& Chen, Jin. 2017. Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193804
Modern Language Association (MLA)
Shi, Xianqing…[et al.]. Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1193804
American Medical Association (AMA)
Shi, Xianqing& Fu, Yongjian& Zhang, SongSong& Ding, Hao& Chen, Jin. Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193804