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Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity
المؤلفون المشاركون
Berrino, L.
De Angelis, A.
Urbanek, Konrad
Cappetta, Donato
Naviglio, Silvio
Sapio, Luigi
Illiano, Michela
Prezioso, Lucia
Rossi, Francesco
Quaini, F.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The production of reactive species is a core of the redox cycling profile of anthracyclines.
However, these molecular characteristics can be viewed as a double-edged sword acting not only on neoplastic cells but also on multiple cellular targets throughout the body.
This phenomenon translates into anthracycline cardiotoxicity that is a serious problem in the growing population of paediatric and adult cancer survivors.
Therefore, better understanding of cellular processes that operate within but also go beyond cardiomyocytes is a necessary step to develop more effective tools for the prevention and treatment of progressive and often severe cardiomyopathy experienced by otherwise successfully treated oncologic patients.
In this review, we focus on oxidative stress-triggered cellular events such as DNA damage, senescence, and cell death implicated in anthracycline cardiovascular toxicity.
The involvement of progenitor cells of cardiac and extracardiac origin as well as different cardiac cell types is discussed, pointing to molecular signals that impact on cell longevity and functional competence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cappetta, Donato& De Angelis, A.& Sapio, Luigi& Prezioso, Lucia& Illiano, Michela& Quaini, F.…[et al.]. 2017. Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193846
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cappetta, Donato…[et al.]. Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1193846
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cappetta, Donato& De Angelis, A.& Sapio, Luigi& Prezioso, Lucia& Illiano, Michela& Quaini, F.…[et al.]. Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193846
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193846
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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