Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity
Joint Authors
Berrino, L.
De Angelis, A.
Urbanek, Konrad
Cappetta, Donato
Naviglio, Silvio
Sapio, Luigi
Illiano, Michela
Prezioso, Lucia
Rossi, Francesco
Quaini, F.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The production of reactive species is a core of the redox cycling profile of anthracyclines.
However, these molecular characteristics can be viewed as a double-edged sword acting not only on neoplastic cells but also on multiple cellular targets throughout the body.
This phenomenon translates into anthracycline cardiotoxicity that is a serious problem in the growing population of paediatric and adult cancer survivors.
Therefore, better understanding of cellular processes that operate within but also go beyond cardiomyocytes is a necessary step to develop more effective tools for the prevention and treatment of progressive and often severe cardiomyopathy experienced by otherwise successfully treated oncologic patients.
In this review, we focus on oxidative stress-triggered cellular events such as DNA damage, senescence, and cell death implicated in anthracycline cardiovascular toxicity.
The involvement of progenitor cells of cardiac and extracardiac origin as well as different cardiac cell types is discussed, pointing to molecular signals that impact on cell longevity and functional competence.
American Psychological Association (APA)
Cappetta, Donato& De Angelis, A.& Sapio, Luigi& Prezioso, Lucia& Illiano, Michela& Quaini, F.…[et al.]. 2017. Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193846
Modern Language Association (MLA)
Cappetta, Donato…[et al.]. Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1193846
American Medical Association (AMA)
Cappetta, Donato& De Angelis, A.& Sapio, Luigi& Prezioso, Lucia& Illiano, Michela& Quaini, F.…[et al.]. Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193846