![](/images/graphics-bg.png)
Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease
المؤلفون المشاركون
Hüttemann, Maik
Shay, Joseph
Lee, Icksoo
Malek, Moh H.
Sinkler, Christopher A.
Kalpage, Hasini
Grossman, Lawrence I.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-16
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain and catalyzes the transfer of electrons from cytochrome c to oxygen.
COX consists of 14 subunits, three and eleven encoded, respectively, by the mitochondrial and nuclear DNA.
Tissue- and condition-specific isoforms have only been reported for COX but not for the other oxidative phosphorylation complexes, suggesting a fundamental requirement to fine-tune and regulate the essentially irreversible reaction catalyzed by COX.
This article briefly discusses the assembly of COX in mammals and then reviews the functions of the six nuclear-encoded COX subunits that are expressed as isoforms in specialized tissues including those of the liver, heart and skeletal muscle, lung, and testes: COX IV-1, COX IV-2, NDUFA4, NDUFA4L2, COX VIaL, COX VIaH, COX VIb-1, COX VIb-2, COX VIIaH, COX VIIaL, COX VIIaR, COX VIIIH/L, and COX VIII-3.
We propose a model in which the isoforms mediate the interconnected regulation of COX by (1) adjusting basal enzyme activity to mitochondrial capacity of a given tissue; (2) allosteric regulation to adjust energy production to need; (3) altering proton pumping efficiency under certain conditions, contributing to thermogenesis; (4) providing a platform for tissue-specific signaling; (5) stabilizing the COX dimer; and (6) modulating supercomplex formation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sinkler, Christopher A.& Kalpage, Hasini& Shay, Joseph& Lee, Icksoo& Malek, Moh H.& Grossman, Lawrence I.…[et al.]. 2017. Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1193853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sinkler, Christopher A.…[et al.]. Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1193853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sinkler, Christopher A.& Kalpage, Hasini& Shay, Joseph& Lee, Icksoo& Malek, Moh H.& Grossman, Lawrence I.…[et al.]. Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1193853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)