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Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease
Joint Authors
Hüttemann, Maik
Shay, Joseph
Lee, Icksoo
Malek, Moh H.
Sinkler, Christopher A.
Kalpage, Hasini
Grossman, Lawrence I.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-16
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain and catalyzes the transfer of electrons from cytochrome c to oxygen.
COX consists of 14 subunits, three and eleven encoded, respectively, by the mitochondrial and nuclear DNA.
Tissue- and condition-specific isoforms have only been reported for COX but not for the other oxidative phosphorylation complexes, suggesting a fundamental requirement to fine-tune and regulate the essentially irreversible reaction catalyzed by COX.
This article briefly discusses the assembly of COX in mammals and then reviews the functions of the six nuclear-encoded COX subunits that are expressed as isoforms in specialized tissues including those of the liver, heart and skeletal muscle, lung, and testes: COX IV-1, COX IV-2, NDUFA4, NDUFA4L2, COX VIaL, COX VIaH, COX VIb-1, COX VIb-2, COX VIIaH, COX VIIaL, COX VIIaR, COX VIIIH/L, and COX VIII-3.
We propose a model in which the isoforms mediate the interconnected regulation of COX by (1) adjusting basal enzyme activity to mitochondrial capacity of a given tissue; (2) allosteric regulation to adjust energy production to need; (3) altering proton pumping efficiency under certain conditions, contributing to thermogenesis; (4) providing a platform for tissue-specific signaling; (5) stabilizing the COX dimer; and (6) modulating supercomplex formation.
American Psychological Association (APA)
Sinkler, Christopher A.& Kalpage, Hasini& Shay, Joseph& Lee, Icksoo& Malek, Moh H.& Grossman, Lawrence I.…[et al.]. 2017. Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1193853
Modern Language Association (MLA)
Sinkler, Christopher A.…[et al.]. Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1193853
American Medical Association (AMA)
Sinkler, Christopher A.& Kalpage, Hasini& Shay, Joseph& Lee, Icksoo& Malek, Moh H.& Grossman, Lawrence I.…[et al.]. Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1193853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193853