Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOSNO Pathway in Rats
المؤلفون المشاركون
Yao, Weifeng
Xu, Jun-mei
Zeng, Ni
Li, Suobei
Ruan, Wei
Xiao, Feng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Sepsis-induced myocardial dysfunction increases mortality in sepsis, yet the underlying mechanism is unclear.
Brain-derived neurotrophic factor (BDNF) has been found to enhance cardiomyocyte function, but whether BDNF has a beneficial effect against septic myocardial dysfunction is unknown.
Septic shock was induced by cecal ligation and puncture (CLP).
BDNF was expressed in primary cardiomyocytes, and its expression was significantly reduced after sepsis.
In rats with sepsis, a sharp decline in survival was observed after CLP, with significantly reduced cardiac BDNF expression, enhanced myocardial fibrosis, elevated oxidative stress, increased myocardial apoptosis, and decreased endothelial nitric oxide (NO) synthase (eNOS) and NO.
Supplementation with recombined BDNF protein (rhBDNF) enhanced myocardial BDNF and increased survival rate with improved cardiac function, reduced oxidative stress, and myocardial apoptosis, which were associated with increased eNOS expression, NO production, and Trk-B, a BDNF receptor.
Pretreatment with NOS inhibitor, N (omega)-nitro-L-arginine methyl ester, abolished the abovementioned BDNF cardioprotective effects without affecting BDNF and Trk-B.
It is concluded that BDNF protects the heart against septic cardiac dysfunction by reducing oxidative stress and apoptosis via Trk-B, and it does so through activation of eNOS/NO pathway.
These findings provide a new treatment strategy for sepsis-induced myocardial dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeng, Ni& Xu, Jun-mei& Yao, Weifeng& Li, Suobei& Ruan, Wei& Xiao, Feng. 2017. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOSNO Pathway in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeng, Ni…[et al.]. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOSNO Pathway in Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1193919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeng, Ni& Xu, Jun-mei& Yao, Weifeng& Li, Suobei& Ruan, Wei& Xiao, Feng. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOSNO Pathway in Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر