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Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOSNO Pathway in Rats
Joint Authors
Yao, Weifeng
Xu, Jun-mei
Zeng, Ni
Li, Suobei
Ruan, Wei
Xiao, Feng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sepsis-induced myocardial dysfunction increases mortality in sepsis, yet the underlying mechanism is unclear.
Brain-derived neurotrophic factor (BDNF) has been found to enhance cardiomyocyte function, but whether BDNF has a beneficial effect against septic myocardial dysfunction is unknown.
Septic shock was induced by cecal ligation and puncture (CLP).
BDNF was expressed in primary cardiomyocytes, and its expression was significantly reduced after sepsis.
In rats with sepsis, a sharp decline in survival was observed after CLP, with significantly reduced cardiac BDNF expression, enhanced myocardial fibrosis, elevated oxidative stress, increased myocardial apoptosis, and decreased endothelial nitric oxide (NO) synthase (eNOS) and NO.
Supplementation with recombined BDNF protein (rhBDNF) enhanced myocardial BDNF and increased survival rate with improved cardiac function, reduced oxidative stress, and myocardial apoptosis, which were associated with increased eNOS expression, NO production, and Trk-B, a BDNF receptor.
Pretreatment with NOS inhibitor, N (omega)-nitro-L-arginine methyl ester, abolished the abovementioned BDNF cardioprotective effects without affecting BDNF and Trk-B.
It is concluded that BDNF protects the heart against septic cardiac dysfunction by reducing oxidative stress and apoptosis via Trk-B, and it does so through activation of eNOS/NO pathway.
These findings provide a new treatment strategy for sepsis-induced myocardial dysfunction.
American Psychological Association (APA)
Zeng, Ni& Xu, Jun-mei& Yao, Weifeng& Li, Suobei& Ruan, Wei& Xiao, Feng. 2017. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOSNO Pathway in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193919
Modern Language Association (MLA)
Zeng, Ni…[et al.]. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOSNO Pathway in Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1193919
American Medical Association (AMA)
Zeng, Ni& Xu, Jun-mei& Yao, Weifeng& Li, Suobei& Ruan, Wei& Xiao, Feng. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOSNO Pathway in Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193919