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Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice
المؤلفون المشاركون
Lagali, Neil
Morikawa, Tetsuro
Yoshida, Koki
Sato, Jun
Harada, Fumiya
Lennikov, Anton
Mukwaya, Anthony
Schaupper, Mira
Uehara, Osamu
Takai, Rie
Horie, Yukihiro
Sakaguchi, Hiroyuki
Wu, Ching-Zong
Kitaichi, Nobuyoshi
Abiko, Yoshihiro
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Purpose.
Astaxanthin (AST) has a strong antioxidant cellular membrane chaperone protective effect.
Recently, a water-soluble nanosized AST (nano-AST) form was produced, which is expected to improve the efficacy of oral intake effects.
The purpose of this study was to examine whether oral nano-AST has therapeutic effects on UV-induced photokeratitis in mice.
Methods.
C57BL/6 mice were administered twice with either nano-AST, AST oil, lutein, or bilberry extracts 3 hours before and shortly before UV irradiation (dose: 400 mJ/cm2).
The corneas were collected 24 hours after irradiation and stained with H&E and TUNEL.
NF-κB, dihydroethidium (DHE), COX-2, p-IκB-α, TNFα, and CD45 expression were evaluated through immunohistochemistry, Western blot analysis, and qPCR.
Results.
Corneal epithelium was significantly thicker in mice orally administered with nano-AST than in the others (p<0.01), with significantly less NF-κB nucleus translocation (p<0.001), and significantly fewer TUNEL cells (p<0.01).
Weaker DHE signals were detected in the nano-AST group (p<0.05) relative to the others.
Furthermore, reduced inflammation and decreased cell death in corneal tissue were observed in the nano-AST group, as indicated by a reduction in the expression of COX-2, p-IκB-α, TNFα, and CD45.
Conclusions.
Oral administration of nano-AST demonstrated a protective effect on UV-induced photokeratitis via antioxidative, anti-inflammatory, and antiapoptotic activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Harada, Fumiya& Morikawa, Tetsuro& Lennikov, Anton& Mukwaya, Anthony& Schaupper, Mira& Uehara, Osamu…[et al.]. 2017. Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193973
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Harada, Fumiya…[et al.]. Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1193973
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Harada, Fumiya& Morikawa, Tetsuro& Lennikov, Anton& Mukwaya, Anthony& Schaupper, Mira& Uehara, Osamu…[et al.]. Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193973
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193973
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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