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Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke
المؤلفون المشاركون
Guimarães-Santos, Adriano
Gomes-Leal, Walace
Souza, Celice C.
Silva, Michelle Castro da
Lopes, Rosana Telma
Cardoso, Marcelo M.
Souza, Lucas Lacerda de
Santos, Ijair Rogério dos
Franco, Edna C. S.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-21
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
We explored the comparative effects of minocycline treatment and intrastriatal BMMC transplantation after experimental striatal stroke in adult rats.
Male Wistar adult rats were divided as follows: saline-treated (N=5), minocycline-treated (N=5), and BMMC-transplanted (N=5) animals.
Animals received intrastriatal microinjections of 80 pmol of endothelin-1 (ET-1).
Behavioral tests were performed at 1, 3, and 7 days postischemia.
Animals were treated with minocycline (50 mg/kg, i.p.) or intrastriatal transplants of 106 BMMCs at 24 h postischemia.
Animals were perfused at 7 days after ischemic induction.
Coronal sections were stained with cresyl violet for gross histopathological analysis and immunolabeled for the identification of neuronal bodies (NeuN), activated microglia/macrophages (ED1), and apoptotic cells (active caspase-3).
BMMC transplantation and minocycline reduced the number of ED1+ cells (p<0.05, ANOVA-Tukey), but BMMC afforded better results.
Both treatments afforded comparable levels of neuronal preservation compared to control (p>0.05).
BMMC transplantation induced a higher decrease in the number of apoptotic cells compared to control and minocycline treatment.
Both therapeutic approaches improved functional recovery in ischemic animals.
The results suggest that BMMC transplantation is more effective in modulating microglial activation and reducing apoptotic cell death than minocycline, although both treatments are equally efficacious on improving neuronal preservation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Souza, Celice C.& Silva, Michelle Castro da& Lopes, Rosana Telma& Cardoso, Marcelo M.& Souza, Lucas Lacerda de& Guimarães-Santos, Adriano…[et al.]. 2017. Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1193978
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Souza, Celice C.…[et al.]. Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1193978
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Souza, Celice C.& Silva, Michelle Castro da& Lopes, Rosana Telma& Cardoso, Marcelo M.& Souza, Lucas Lacerda de& Guimarães-Santos, Adriano…[et al.]. Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1193978
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193978
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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