![](/images/graphics-bg.png)
Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke
Joint Authors
Guimarães-Santos, Adriano
Gomes-Leal, Walace
Souza, Celice C.
Silva, Michelle Castro da
Lopes, Rosana Telma
Cardoso, Marcelo M.
Souza, Lucas Lacerda de
Santos, Ijair Rogério dos
Franco, Edna C. S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
We explored the comparative effects of minocycline treatment and intrastriatal BMMC transplantation after experimental striatal stroke in adult rats.
Male Wistar adult rats were divided as follows: saline-treated (N=5), minocycline-treated (N=5), and BMMC-transplanted (N=5) animals.
Animals received intrastriatal microinjections of 80 pmol of endothelin-1 (ET-1).
Behavioral tests were performed at 1, 3, and 7 days postischemia.
Animals were treated with minocycline (50 mg/kg, i.p.) or intrastriatal transplants of 106 BMMCs at 24 h postischemia.
Animals were perfused at 7 days after ischemic induction.
Coronal sections were stained with cresyl violet for gross histopathological analysis and immunolabeled for the identification of neuronal bodies (NeuN), activated microglia/macrophages (ED1), and apoptotic cells (active caspase-3).
BMMC transplantation and minocycline reduced the number of ED1+ cells (p<0.05, ANOVA-Tukey), but BMMC afforded better results.
Both treatments afforded comparable levels of neuronal preservation compared to control (p>0.05).
BMMC transplantation induced a higher decrease in the number of apoptotic cells compared to control and minocycline treatment.
Both therapeutic approaches improved functional recovery in ischemic animals.
The results suggest that BMMC transplantation is more effective in modulating microglial activation and reducing apoptotic cell death than minocycline, although both treatments are equally efficacious on improving neuronal preservation.
American Psychological Association (APA)
Souza, Celice C.& Silva, Michelle Castro da& Lopes, Rosana Telma& Cardoso, Marcelo M.& Souza, Lucas Lacerda de& Guimarães-Santos, Adriano…[et al.]. 2017. Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1193978
Modern Language Association (MLA)
Souza, Celice C.…[et al.]. Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1193978
American Medical Association (AMA)
Souza, Celice C.& Silva, Michelle Castro da& Lopes, Rosana Telma& Cardoso, Marcelo M.& Souza, Lucas Lacerda de& Guimarães-Santos, Adriano…[et al.]. Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1193978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1193978