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Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
المؤلفون المشاركون
de Lima Rosa, Josiane
Villela e Silva, Patrícia
da Cunha Martins, Airton
Missassi, Gabriela
De Grava Kempinas, Wilma
dos Santos Borges, Cibele
Barbosa Junior, Fernando
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed.
Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters.
The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days.
Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation.
It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group.
Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups.
Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress.
Moreover, varicocele showed bilateral deleterious effects without interfering with fertility.
Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages.
For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Missassi, Gabriela& dos Santos Borges, Cibele& de Lima Rosa, Josiane& Villela e Silva, Patrícia& da Cunha Martins, Airton& Barbosa Junior, Fernando…[et al.]. 2017. Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Missassi, Gabriela…[et al.]. Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Missassi, Gabriela& dos Santos Borges, Cibele& de Lima Rosa, Josiane& Villela e Silva, Patrícia& da Cunha Martins, Airton& Barbosa Junior, Fernando…[et al.]. Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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