Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
Joint Authors
de Lima Rosa, Josiane
Villela e Silva, Patrícia
da Cunha Martins, Airton
Missassi, Gabriela
De Grava Kempinas, Wilma
dos Santos Borges, Cibele
Barbosa Junior, Fernando
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed.
Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters.
The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days.
Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation.
It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group.
Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups.
Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress.
Moreover, varicocele showed bilateral deleterious effects without interfering with fertility.
Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages.
For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition.
American Psychological Association (APA)
Missassi, Gabriela& dos Santos Borges, Cibele& de Lima Rosa, Josiane& Villela e Silva, Patrícia& da Cunha Martins, Airton& Barbosa Junior, Fernando…[et al.]. 2017. Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194005
Modern Language Association (MLA)
Missassi, Gabriela…[et al.]. Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194005
American Medical Association (AMA)
Missassi, Gabriela& dos Santos Borges, Cibele& de Lima Rosa, Josiane& Villela e Silva, Patrícia& da Cunha Martins, Airton& Barbosa Junior, Fernando…[et al.]. Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194005