Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin
المؤلفون المشاركون
Vásquez-Garzón, Verónica R.
Villa-Treviño, Saúl
Carrasco-Torres, Gabriela
Baltiérrez-Hoyos, Rafael
Andrade-Jorge, Erik
Trujillo-Ferrara, José Guadalupe
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-10
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The inflammatory condition of malignant tumors continually exposes cancer cells to reactive oxygen species, an oxidizing condition that leads to the activation of the antioxidant defense system.
A similar activation occurs with glutathione production.
This oxidant condition enables tumor cells to maintain the energy required for growth, proliferation, and evasion of cell death.
The objective of the present study was to determine the effect on hepatocellular carcinoma cells of a combination treatment with maleic anhydride derivatives (prooxidants) and quercetin (an antioxidant).
The results show that the combination of a prooxidant/antioxidant had a cytotoxic effect on HuH7 and HepG2 liver cancer cells, but not on either of two normal human epithelial cell lines or on primary hepatocytes.
The combination treatment triggered apoptosis in hepatocellular carcinoma cells by activating the intrinsic pathway and causing S phase arrest during cell cycle progression.
There is also clear evidence of a modification in cytoskeletal actin and nucleus morphology at 24 and 48 h posttreatment.
Thus, the current data suggest that the combination of two anticarcinogenic drugs, a prooxidant followed by an antioxidant, can be further explored for antitumor potential as a new treatment strategy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carrasco-Torres, Gabriela& Baltiérrez-Hoyos, Rafael& Andrade-Jorge, Erik& Villa-Treviño, Saúl& Trujillo-Ferrara, José Guadalupe& Vásquez-Garzón, Verónica R.. 2017. Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194144
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carrasco-Torres, Gabriela…[et al.]. Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1194144
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carrasco-Torres, Gabriela& Baltiérrez-Hoyos, Rafael& Andrade-Jorge, Erik& Villa-Treviño, Saúl& Trujillo-Ferrara, José Guadalupe& Vásquez-Garzón, Verónica R.. Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194144
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194144
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر