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Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin
Joint Authors
Vásquez-Garzón, Verónica R.
Villa-Treviño, Saúl
Carrasco-Torres, Gabriela
Baltiérrez-Hoyos, Rafael
Andrade-Jorge, Erik
Trujillo-Ferrara, José Guadalupe
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The inflammatory condition of malignant tumors continually exposes cancer cells to reactive oxygen species, an oxidizing condition that leads to the activation of the antioxidant defense system.
A similar activation occurs with glutathione production.
This oxidant condition enables tumor cells to maintain the energy required for growth, proliferation, and evasion of cell death.
The objective of the present study was to determine the effect on hepatocellular carcinoma cells of a combination treatment with maleic anhydride derivatives (prooxidants) and quercetin (an antioxidant).
The results show that the combination of a prooxidant/antioxidant had a cytotoxic effect on HuH7 and HepG2 liver cancer cells, but not on either of two normal human epithelial cell lines or on primary hepatocytes.
The combination treatment triggered apoptosis in hepatocellular carcinoma cells by activating the intrinsic pathway and causing S phase arrest during cell cycle progression.
There is also clear evidence of a modification in cytoskeletal actin and nucleus morphology at 24 and 48 h posttreatment.
Thus, the current data suggest that the combination of two anticarcinogenic drugs, a prooxidant followed by an antioxidant, can be further explored for antitumor potential as a new treatment strategy.
American Psychological Association (APA)
Carrasco-Torres, Gabriela& Baltiérrez-Hoyos, Rafael& Andrade-Jorge, Erik& Villa-Treviño, Saúl& Trujillo-Ferrara, José Guadalupe& Vásquez-Garzón, Verónica R.. 2017. Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194144
Modern Language Association (MLA)
Carrasco-Torres, Gabriela…[et al.]. Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1194144
American Medical Association (AMA)
Carrasco-Torres, Gabriela& Baltiérrez-Hoyos, Rafael& Andrade-Jorge, Erik& Villa-Treviño, Saúl& Trujillo-Ferrara, José Guadalupe& Vásquez-Garzón, Verónica R.. Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194144