The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity
المؤلفون المشاركون
Yan, Liang-Jun
Zhang, Ce
Yang, Xiaorong
Si, Peipei
Qin, Huaping
Yin, Litian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Silent information regulator 1 (SIRT1), an NAD+-dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism, and cellular aging and has become an important therapeutic target across a range of diseases.
Recent research has demonstrated that SIRT1 possesses neuroprotective effects; however, it is unknown whether it protects neurons from NMDA-mediated neurotoxicity.
In the present study, by activation of SIRT1 using resveratrol (RSV) in cultured cortical neurons or by overexpression of SIRT1 in SH-SY5Y cell, we aimed to evaluate the roles of SIRT1 in NMDA-induced excitotoxicity.
Our results showed that RSV or overexpression of SIRT1 elicited inhibitory effects on NMDA-induced excitotoxicity including a decrease in cell viability, an increase in lactate dehydrogenase (LDH) release, and a decrease in the number of living cells as measured by CCK-8 assay, LDH test, and Calcein-AM and PI double staining.
RSV or overexpression of SIRT1 significantly improved SIRT1 deacetylase activity in the excitotoxicity model.
Further study suggests that overexpression of SIRT1 partly suppressed an NMDA-induced increase in p53 acetylation.
These results indicate that SIRT1 activation by either RSV or overexpression of SIRT1 can exert neuroprotective effects partly by inhibiting p53 acetylation in NMDA-induced neurotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xiaorong& Si, Peipei& Qin, Huaping& Yin, Litian& Yan, Liang-Jun& Zhang, Ce. 2017. The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194173
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xiaorong…[et al.]. The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1194173
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xiaorong& Si, Peipei& Qin, Huaping& Yin, Litian& Yan, Liang-Jun& Zhang, Ce. The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194173
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194173
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر