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The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity
المؤلفون المشاركون
Yan, Liang-Jun
Zhang, Ce
Yang, Xiaorong
Si, Peipei
Qin, Huaping
Yin, Litian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Silent information regulator 1 (SIRT1), an NAD+-dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism, and cellular aging and has become an important therapeutic target across a range of diseases.
Recent research has demonstrated that SIRT1 possesses neuroprotective effects; however, it is unknown whether it protects neurons from NMDA-mediated neurotoxicity.
In the present study, by activation of SIRT1 using resveratrol (RSV) in cultured cortical neurons or by overexpression of SIRT1 in SH-SY5Y cell, we aimed to evaluate the roles of SIRT1 in NMDA-induced excitotoxicity.
Our results showed that RSV or overexpression of SIRT1 elicited inhibitory effects on NMDA-induced excitotoxicity including a decrease in cell viability, an increase in lactate dehydrogenase (LDH) release, and a decrease in the number of living cells as measured by CCK-8 assay, LDH test, and Calcein-AM and PI double staining.
RSV or overexpression of SIRT1 significantly improved SIRT1 deacetylase activity in the excitotoxicity model.
Further study suggests that overexpression of SIRT1 partly suppressed an NMDA-induced increase in p53 acetylation.
These results indicate that SIRT1 activation by either RSV or overexpression of SIRT1 can exert neuroprotective effects partly by inhibiting p53 acetylation in NMDA-induced neurotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xiaorong& Si, Peipei& Qin, Huaping& Yin, Litian& Yan, Liang-Jun& Zhang, Ce. 2017. The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194173
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xiaorong…[et al.]. The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1194173
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xiaorong& Si, Peipei& Qin, Huaping& Yin, Litian& Yan, Liang-Jun& Zhang, Ce. The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1194173
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194173
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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