Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging
المؤلفون المشاركون
Medkour, Younes
Dakik, Paméla
McAuley, Mélissa
Mohammad, Karamat
Mitrofanova, Darya
Titorenko, Vladimir I.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-16
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The functional state of mitochondria is vital to cellular and organismal aging in eukaryotes across phyla.
Studies in the yeast Saccharomyces cerevisiae have provided evidence that age-related changes in some aspects of mitochondrial functionality can create certain molecular signals.
These signals can then define the rate of cellular aging by altering unidirectional and bidirectional communications between mitochondria and other organelles.
Several aspects of mitochondrial functionality are known to impact the replicative and/or chronological modes of yeast aging.
They include mitochondrial electron transport, membrane potential, reactive oxygen species, and protein synthesis and proteostasis, as well as mitochondrial synthesis of iron-sulfur clusters, amino acids, and NADPH.
Our recent findings have revealed that the composition of mitochondrial membrane lipids is one of the key aspects of mitochondrial functionality affecting yeast chronological aging.
We demonstrated that exogenously added lithocholic bile acid can delay chronological aging in yeast because it elicits specific changes in mitochondrial membrane lipids.
These changes allow mitochondria to operate as signaling platforms that delay yeast chronological aging by orchestrating an institution and maintenance of a distinct cellular pattern.
In this review, we discuss molecular and cellular mechanisms underlying the essential role of mitochondrial membrane lipids in yeast chronological aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Medkour, Younes& Dakik, Paméla& McAuley, Mélissa& Mohammad, Karamat& Mitrofanova, Darya& Titorenko, Vladimir I.. 2017. Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Medkour, Younes…[et al.]. Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1194183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Medkour, Younes& Dakik, Paméla& McAuley, Mélissa& Mohammad, Karamat& Mitrofanova, Darya& Titorenko, Vladimir I.. Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر