![](/images/graphics-bg.png)
Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging
Joint Authors
Medkour, Younes
Dakik, Paméla
McAuley, Mélissa
Mohammad, Karamat
Mitrofanova, Darya
Titorenko, Vladimir I.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The functional state of mitochondria is vital to cellular and organismal aging in eukaryotes across phyla.
Studies in the yeast Saccharomyces cerevisiae have provided evidence that age-related changes in some aspects of mitochondrial functionality can create certain molecular signals.
These signals can then define the rate of cellular aging by altering unidirectional and bidirectional communications between mitochondria and other organelles.
Several aspects of mitochondrial functionality are known to impact the replicative and/or chronological modes of yeast aging.
They include mitochondrial electron transport, membrane potential, reactive oxygen species, and protein synthesis and proteostasis, as well as mitochondrial synthesis of iron-sulfur clusters, amino acids, and NADPH.
Our recent findings have revealed that the composition of mitochondrial membrane lipids is one of the key aspects of mitochondrial functionality affecting yeast chronological aging.
We demonstrated that exogenously added lithocholic bile acid can delay chronological aging in yeast because it elicits specific changes in mitochondrial membrane lipids.
These changes allow mitochondria to operate as signaling platforms that delay yeast chronological aging by orchestrating an institution and maintenance of a distinct cellular pattern.
In this review, we discuss molecular and cellular mechanisms underlying the essential role of mitochondrial membrane lipids in yeast chronological aging.
American Psychological Association (APA)
Medkour, Younes& Dakik, Paméla& McAuley, Mélissa& Mohammad, Karamat& Mitrofanova, Darya& Titorenko, Vladimir I.. 2017. Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194183
Modern Language Association (MLA)
Medkour, Younes…[et al.]. Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1194183
American Medical Association (AMA)
Medkour, Younes& Dakik, Paméla& McAuley, Mélissa& Mohammad, Karamat& Mitrofanova, Darya& Titorenko, Vladimir I.. Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194183