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NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage
المؤلفون المشاركون
Wang, Fuchun
Li, Tie
Wu, Junduo
Song, Yanyan
Pan, Chenyu
Zhou, Shengzhu
Liu, Lingyun
Ha, Lijuan
Liu, Xiaona
Tian, Jingyan
Wu, Hao
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Activation of nuclear factor erythroid 2-related factor 2 (NRF2) has been found to ameliorate diabetic testicular damage (DTD) in rodents.
However, it was unclear whether NRF2 is required for these approaches in DTD.
Epigallocatechin gallate (EGCG) is a potent activator of NRF2 and has shown beneficial effects on multiple diabetic complications.
However, the effect of EGCG has not been studied in DTD.
The present study aims to explore the role of NRF2 in both self and EGCG protection against DTD.
Therefore, streptozotocin-induced diabetic C57BL/6 wild type (WT) and Nrf2 knockout (KO) mice were treated in the presence or absence of EGCG, for 24 weeks.
The Nrf2 KO mice exhibited more significant diabetes-induced loss in testicular weight and spermatozoa count, and increase in testicular apoptotic cell death, as compared with the WT mice.
EGCG activated NRF2 expression and function, preserved testicular weight and spermatozoa count, and attenuated testicular apoptotic cell death, endoplasmic reticulum stress, inflammation, and oxidative damage in the WT diabetic mice, but not the Nrf2 KO diabetic mice.
The present study demonstrated for the first time that NRF2 plays a critical role in both self and EGCG protection against DTD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Chenyu& Zhou, Shengzhu& Wu, Junduo& Liu, Lingyun& Song, Yanyan& Li, Tie…[et al.]. 2017. NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194258
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Chenyu…[et al.]. NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194258
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Chenyu& Zhou, Shengzhu& Wu, Junduo& Liu, Lingyun& Song, Yanyan& Li, Tie…[et al.]. NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194258
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194258
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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